Bcs Class 4 Drugs
Bcs Class 4 Drugs Dissolution
Preview Text Soundararajan_Enhancing the Bioavailability of BCS ClassIV drugs using polymeric nanoparticles.pdf Abstract Hydrophobic drugs that are P-gp substrates (BCS Class IV) such as paclitaxel, CUDC-101 etc. Pose a serious challenge for oral drug delivery. Polymeric amphiphiles such as N-palmitoyl-N-monomethyl-N,N-dimethyl-N,N,N-trimethyl-6-O-glycolchitosan (GCPQ) are capable of enhancing the bioavailability of hydrophobic drugs by forming nanoparticles. The general hypothesis is that the physicochemical properties of the polymer will affect the colloidal stability, encapsulation efficiency and absorption of hydrophobic drugs. Free online mobile sms tracker. The main aims of the project are as follows: a) to examine the feasibility of using GCPQ with different characteristics, for the oral and subcutaneous delivery of CUDC-101 and b) to examine the effect of N-(2-phenoxyacetamide)-6-O-glycolchitosan (GCPh) on the P-gp efflux of paclitaxel. GCPh, a new polymeric amphiphile was synthesized by conjugating glycol chitosan to phenoxy acetic acid.